Development of novel pyrrole synthesis for the preparation of intermediates of bioactive pyrrole alkaloids

We have developed a novel method for the synthesis of 3,4-diarylpyrrole-2,5-dicarboxylates via α-diazo esters, which are easily obtained from phenylalanine derivatives. Utilizing this method, intermediates of bioactive compounds having the structure of 3,4-diarylpyrrole-2,5-dicarboxylates were synth...

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Bibliographic Details
Published inTetrahedron letters Vol. 50; no. 33; pp. 4762 - 4765
Main Authors Yasui, Eiko, Wada, Masao, Takamura, Norio
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 19.08.2009
Elsevier
Subjects
3,4-Diarylpyrrole-2,5-dicarboxylates
Chemistry
Chemistry, Organic
Hydrazone
Physical Sciences
Piloty-Robinson pyrrole synthesis
Polycitone
Science & Technology
Storniamide
α-Diazo ester
3,4-Diarylpyrrole-2,5-dicarboxylates
POLYCITONE-B
ROUTE
IMINIUM SALT DERIVATIVES
PERMETHYL STORNIAMIDE-A
NINGALIN
ALPHA-DIAZO ESTERS
PEPTIDES
ETHER
3,4-Diarylpyrrole-2,5-dicarboxylates, Piloty-Robinson pyrrole synthesis
alpha-Diazo ester
Polycitone
Hydrazone
Storniamide
EFFICIENT RELAY SYNTHESES
AMINO-ACID ESTERS
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Summary:We have developed a novel method for the synthesis of 3,4-diarylpyrrole-2,5-dicarboxylates via α-diazo esters, which are easily obtained from phenylalanine derivatives. Utilizing this method, intermediates of bioactive compounds having the structure of 3,4-diarylpyrrole-2,5-dicarboxylates were synthesized.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2009.06.012