Water-based biphasic media for exothermic reactions: green chemistry strategy for the large scale preparation of clofibric acid and analogues

• Published in: Tetrahedron letters Vol. 46; no. 17; pp. 3011 - 3013
• Main Authors: Bose, Ajay K., Manhas, Maghar S., Ganguly, Subhendu N., Pednekar, Suhas, Mandadi, Arun
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 25.04.2005; Elsevier
• Subjects: 2-Methyl-2-aryloxypropanoic acids; Chemistry; Chemistry, Organic; Clofibric acid; Energy-efficient process; Exothermic reaction; Physical Sciences; Science & Technology; Water-based biphasic reaction media; 2-Methyl-2-aryloxypropanoic acids; Energy-efficient process; Water-based biphasic reaction media; Clofibric acid; Exothermic reaction; exothermic reaction; BIGINELLI REACTION; water-based biphasic reaction media; clofibric acid; 2-methyl-2-aryloxypropanoic acids; energy-efficient process
• ISSN: 0040-4039; 1873-3581
• DOI: 10.1016/j.tetlet.2005.03.025

An eco-friendly improved procedure is described for the synthesis of clofibric acid and analogues. A water-based biphasic reaction process has been developed for conducting exothermic reactions without organic solvents. This procedure is rapid, simple, and suitable for small scale synthesis as well as larger (multi-molar) scale reactions. The preparation of several hundred grams of clofibric acid and analogues by this eco-friendly and energy-efficient procedure is described. Smaller amounts of these compounds were prepared by the friction-activated ‘Grindstone Chemistry’ method described previously.