Insights into brain tumor diagnosis: exploring in situ hybridization techniques
Diagnosing brain tumors is critical due to their complex nature. This review explores the potential of hybridization for diagnosing brain neoplasms, examining their attributes and applications in neurology and oncology. The review surveys literature and cross-references findings with the OMIM databa...
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Published in | Frontiers in neurology Vol. 15; p. 1393572 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Media S.A
03.07.2024
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Subjects | |
Online Access | Get full text |
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Summary: | Diagnosing brain tumors is critical due to their complex nature. This review explores the potential of
hybridization for diagnosing brain neoplasms, examining their attributes and applications in neurology and oncology.
The review surveys literature and cross-references findings with the OMIM database, examining 513 records. It pinpoints mutations suitable for
hybridization and identifies common chromosomal and gene anomalies in brain tumors. Emphasis is placed on mutations' clinical implications, including prognosis and drug sensitivity.
Amplifications in EGFR, MDM2, and MDM4, along with Y chromosome loss, chromosome 7 polysomy, and deletions of PTEN, CDKN2/p16, TP53, and DMBT1, correlate with poor prognosis in glioma patients. Protective genetic changes in glioma include increased expression of ADGRB3/1, IL12B, DYRKA1, VEGFC, LRRC4, and BMP4. Elevated MMP24 expression worsens prognosis in glioma, oligodendroglioma, and meningioma patients. Meningioma exhibits common chromosomal anomalies like loss of chromosomes 1, 9, 17, and 22, with specific genes implicated in their development. Main occurrences in medulloblastoma include the formation of isochromosome 17q and SHH signaling pathway disruption. Increased expression of BARHL1 is associated with prolonged survival. Adenomas mutations were reviewed with a focus on adenoma-carcinoma transition and different subtypes, with MMP9 identified as the main metalloprotease implicated in tumor progression.
Molecular-genetic diagnostics for common brain tumors involve diverse genetic anomalies.
hybridization shows promise for diagnosing and prognosticating tumors. Detecting tumor-specific alterations is vital for prognosis and treatment. However, many mutations require other methods, hindering
hybridization from becoming the primary diagnostic method. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 Edited by: Kalpana K. Shrivastava, Defence Institute of Physiology and Allied Sciences (DRDO), India Haroon Ahmad, University of Maryland School of Medicine, United States Reviewed by: Olga Makarova, Russian National Research Center of Surgery named after B.V. Petrovsky, Russia |
ISSN: | 1664-2295 1664-2295 |
DOI: | 10.3389/fneur.2024.1393572 |