Thermoanalytical behaviour of some coating free films

• Published in: Journal of thermal analysis and calorimetry Vol. 89; no. 3; pp. 793 - 797
• Main Authors: REGDON, G, KOSA, A, ERÖS, I, PINTYE-HODI, K
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer 01.09.2007
• Subjects: Analysis; Biological and medical sciences; General pharmacology; Medical sciences; Pharmacology. Drug treatments; Differential scanning calorimetry; Film; Controlled release form; microcrystalline cellulose; free films; LustreClear; Storage stability; DSC; Cellulose derivatives; Eudragit NE 30 D; Dosage form; Solid form; storage conditions; Thermal analysis; Carrageenan; Coating; Methacrylate copolymer; Polysaccharide
• ISSN: 1388-6150; 1588-2926; 1572-8943
• DOI: 10.1007/s10973-006-7566-6

Differential scanning calorimetry (DSC) was used in the investigation of the behaviour of coating free films. The films were produced from two film-forming polymers which are chemically different but equally used for producing controlled-release dosage forms: Eudragit NE 30 D (synthetically produced polymethacrylate copolymer) and LustreClear product (mixture containing natural and semi-synthetic components: microcrystalline cellulose, hydroxy-ethyl cellulose, carrageenan and polyethylene glycol). During their comparative analysis the characteristic parameters of the DSC curves obtained with dynamic measurement method were used and their changes as a function of storage conditions and storage time were observed. It was found that the thermoanalytical behaviour of the examined methacrylate-based Eudragit NE and cellulose-based LustreClear films was different. The specific enthalpy change of Eudragit NE fresh films was very little, but it increased considerably during storage. The specific enthalpy change of LustreClear films was much greater but its value shows only a slight further increase during storage. The results obtained help to choose the proper temperature for coating and drying.