Effect of metallization on porphyrin photoacoustic response

• Published in: Chemical physics letters Vol. 738; p. 136875
• Main Authors: Amado, André Miele, Uliana, João Henrique, Pavan, Theo Zeferino, Borissevitch, Iouri
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.01.2020
• Subjects: Paramagnetic and heavy atom effects; Photoacoustic; Photothermic effect; Porphyrins and their metal complexes; Photoacoustic; Paramagnetic and heavy atom effects; Photothermic effect; Porphyrins and their metal complexes
• ISSN: 0009-2614; 1873-4448
• DOI: 10.1016/j.cplett.2019.136875

[Display omitted] •Photoacoustic imaging can visualize small neoplastic lesions inside normal tissues.•Photoacoustic imaging has been evaluated with porphyrins and their derivatives.•Porphyrins can increase the neoplastic photoacoustic response.•The porphyrin complexation with metal ions increases the photoacoustic response. Photoacoustic imaging (PAI) has been evaluated to visualize small neoplastic lesions inside normal tissues. PAI is based on the detection of pressure waves generated due to the absorption of light energy by a photosensitizer (PS) within the tissue. Porphyrins possess high affinity to tumor tissue thus can be considered as an appropriate PS. PS complexation with metals can increase the heat production at the PS excitation; therefore, increasing the PA response. We have demonstrated the increase of the TPPS4 and TMPyP porphyrin PA response at their complexation with Fe3+,Mn3+,Cu2+ and Zn2+ metal ions in aqueous solutions.