Enantioselective synthesis of ( S)-dapoxetine

An efficient enantioselective synthesis leading directly to (+)-( S)-dapoxetine has been described for the first time using a Sharpless asymmetric dihydroxylation, Barton–McCombie deoxygention, and Mitsunobu reaction as the key steps.

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Bibliographic Details
Published inTetrahedron: asymmetry Vol. 18; no. 17; pp. 2099 - 2103
Main Authors Siddiqui, Shafi A., Srinivasan, Kumar V.
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 04.09.2007
Elsevier
Subjects
Chemistry
Chemistry, Inorganic & Nuclear
Chemistry, Organic
Chemistry, Physical
Physical Sciences
Science & Technology
ASYMMETRIC-SYNTHESIS
DAPOXETINE
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Summary:An efficient enantioselective synthesis leading directly to (+)-( S)-dapoxetine has been described for the first time using a Sharpless asymmetric dihydroxylation, Barton–McCombie deoxygention, and Mitsunobu reaction as the key steps.
ISSN:0957-4166
1362-511X
DOI:10.1016/j.tetasy.2007.07.028