ROS induced pyroptosis in inflammatory disease and cancer

Pyroptosis, a form of caspase-1-dependent cell death, also known as inflammation-dependent death, plays a crucial role in diseases such as stroke, heart disease, or tumors. Since its elucidation, pyroptosis has attracted widespread attention from various sectors. Reactive oxygen species (ROS) can re...

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Published inFrontiers in immunology Vol. 15; p. 1378990
Main Authors Wang, Jingsong, Wu, Ziyong, Zhu, Min, Zhao, Yang, Xie, Jingwen
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 01.07.2024
Subjects
Animals
cell death
Humans
Immunology
inflammation
Inflammation - immunology
Inflammation - metabolism
Neoplasms - etiology
Neoplasms - immunology
Neoplasms - metabolism
Neoplasms - pathology
Pyroptosis
Reactive Oxygen Species - metabolism
ROS
Signal Transduction
tumor
pyroptosis
cell death
inflammation
tumor
ROS
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Summary:Pyroptosis, a form of caspase-1-dependent cell death, also known as inflammation-dependent death, plays a crucial role in diseases such as stroke, heart disease, or tumors. Since its elucidation, pyroptosis has attracted widespread attention from various sectors. Reactive oxygen species (ROS) can regulate numerous cellular signaling pathways. Through further research on ROS and pyroptosis, the level of ROS has been revealed to be pivotal for the occurrence of pyroptosis, establishing a close relationship between the two. This review primarily focuses on the molecular mechanisms of ROS and pyroptosis in tumors and inflammatory diseases, exploring key proteins that may serve as drug targets linking ROS and pyroptosis and emerging fields targeting pyroptosis. Additionally, the potential future development of compounds and proteins that influence ROS-regulated cell pyroptosis is anticipated, aiming to provide insights for the development of anti-tumor and anti-inflammatory drugs.
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Reviewed by: Laurel Hind, University of Colorado Boulder, United States
These authors have contributed equally to this work and share first authorship
Ruoxi Yuan, Hospital for Special Surgery, United States
Edited by: Keqiang Chen, National Cancer Institute at Frederick (NIH), United States
Gajendra M. Jogdand, National Cancer Institute at Frederick (NIH), United States
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2024.1378990