The oncostatic effect of methyl-CCNU on various experimental lymphoreticular neoplasms

• Published in: Leukemia research Vol. 6; no. 1; pp. 89 - 95
• Main Authors: Peled, A., Perk, K., Haran-Ghera, N., Chirigos, M.A.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 1982
• Subjects: 9,10-Dimethyl-1,2-benzanthracene; Animals; Blood Cell Count; Body Weight; Drug Administration Schedule; Drug Evaluation, Preclinical; experimental lymphoreticular neoplasms; Female; Hematocrit; Leukemia, Experimental - drug therapy; Leukemia, Experimental - etiology; Leukemia, Radiation-Induced - drug therapy; Methyl-CCNU; Mice; Mice, Inbred Strains; Nitrosourea Compounds - therapeutic use; Precancerous Conditions - drug therapy; Precancerous Conditions - etiology; Retroviridae; Semustine - therapeutic use; 12-dimethyl benz(a) anthracene; 1 -(2 -chloroethyl)-3-(methyl-cyclohexyl)-1-nitroso-trans-urea; Methyl-CCNU; experimental lymphoreticular neoplasms; 7
• ISSN: 0145-2126; 1873-5835
• DOI: 10.1016/0145-2126(82)90047-9

Studies on the chemotherapeutic potential of methyl-CCNU on experimental leukemias were undertaken. A number of murine transplantable in vivo lines (chemical carcinogen-induced T and B leukemias; radiation- and viral-induced T leukemias of C57BL/6, C3H/eb and SJL/J origin: radiation-induced myeloid leukemias and spontaneous reticulum cell neoplasms of SJL;J mine) were used in these studies. The optimal dose of methyl-CCNU and optimal timing of administration were extensively investigated on two sample lines of T cell leukemias of C57BL/6 mice. Leukemic cell eradication could be achieved in almost all of the different leukemias treated, irrespective of whether induction was brought about by chemical or physical means or due to a viral leukemogenic agent. Studies undertaken to elucidate the effect of methyl-CCNU on the establishment of preleukemic cells following induction of leukemia by the radiation leukemia virus (RadLV) or by total body irradiation. indicated the oncostatic effect of methyl-CCNU on early preleukemic cells.