Organocatalytic α-oxybenzoylation of aldehydes

A simple method for the asymmetric α-oxybenzoylation of aldehydes is presented. Treatment of a series of aldehydes with benzoyl peroxide in the presence of a MacMillan imidazolidinone leads directly to the α-oxybenzoylated product with excellent levels of asymmetric induction.

Saved in:
Bibliographic Details
Published inTetrahedron letters Vol. 50; no. 26; pp. 3625 - 3627
Main Authors Vaismaa, Matti J.P., Yau, Sze Chak, Tomkinson, Nicholas C.O.
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 01.07.2009
Elsevier
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
ORGANIC CATALYSIS
OXIDATION
ALCOHOLS
ROUTE
1,2-DIOLS
CARBONYL-COMPOUNDS
AMINOOXYLATION
STRATEGIES
Online AccessGet full text

Cover

More Information
Summary:A simple method for the asymmetric α-oxybenzoylation of aldehydes is presented. Treatment of a series of aldehydes with benzoyl peroxide in the presence of a MacMillan imidazolidinone leads directly to the α-oxybenzoylated product with excellent levels of asymmetric induction.
Bibliography:researchfish
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2009.03.082