Mathematical analysis and application of a cholera transmission model with waning vaccine-induced immunity

In this paper, a cholera infection model with vaccination is investigated, in which hyperinfectious and hypoinfectious vibrios, both human-to-human and environment-to-human transmission pathways, and waning vaccine-induced immunity are considered. The basic reproduction number is calculated and veri...

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Bibliographic Details
Published inNonlinear analysis: real world applications Vol. 58; p. 103232
Main Authors Bai, Ning, Song, Chenwei, Xu, Rui
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.04.2021
Subjects
Cholera transmission
Hyperinfectious vibrios
Hypoinfectious vibrios
Sensitivity analysis
Stability
Waning vaccine-induced immunity
Cholera transmission
Stability
Sensitivity analysis
Hyperinfectious vibrios
Hypoinfectious vibrios
Waning vaccine-induced immunity
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Summary:In this paper, a cholera infection model with vaccination is investigated, in which hyperinfectious and hypoinfectious vibrios, both human-to-human and environment-to-human transmission pathways, and waning vaccine-induced immunity are considered. The basic reproduction number is calculated and verified to be a threshold determining the global dynamics of the model. In addition, an application is demonstrated by investigating the cholera outbreak in Somalia, and the relevant control measures in the short term are given by elasticity and sensitivity analysis.
ISSN:1468-1218
1878-5719
DOI:10.1016/j.nonrwa.2020.103232