Enantioseparation of (RS)-ibuprofen by closed recycling high-speed counter-current chromatography using hydroxypropyl-β-cyclodextrin as chiral selector

• Published in: Tetrahedron: asymmetry Vol. 27; no. 7-8; pp. 301 - 306
• Main Authors: Rong, Liya, Liu, Qi, Wang, Jun, Zeng, Hualiang, Yang, Hua, Chen, Xiaoqing
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.05.2016

[Display omitted] High-speed counter-current chromatography combined with closed recycling elution mode was developed to enantioseparate (RS)-ibuprofen by using hydroxypropyl-β-cyclodextrin (HP-β-CD) as the chiral selector. Key parameters for high-speed counter-current chromatography resolution incl...