Enantioseparation of (RS)-ibuprofen by closed recycling high-speed counter-current chromatography using hydroxypropyl-β-cyclodextrin as chiral selector
[Display omitted] High-speed counter-current chromatography combined with closed recycling elution mode was developed to enantioseparate (RS)-ibuprofen by using hydroxypropyl-β-cyclodextrin (HP-β-CD) as the chiral selector. Key parameters for high-speed counter-current chromatography resolution incl...
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Published in | Tetrahedron: asymmetry Vol. 27; no. 7-8; pp. 301 - 306 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Elsevier Ltd
01.05.2016
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Online Access | Get full text |
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Summary: | [Display omitted]
High-speed counter-current chromatography combined with closed recycling elution mode was developed to enantioseparate (RS)-ibuprofen by using hydroxypropyl-β-cyclodextrin (HP-β-CD) as the chiral selector. Key parameters for high-speed counter-current chromatography resolution including the concentration of HP-β-CD, the two-phase solvent system composition, equilibrium temperature, and the pH of aqueous phase were extensively investigated. Under the optimized conditions, the enantiomers of ibuprofen were successfully separated by preparative recycling high-speed counter-current chromatography and the resulting enantiopurity of each enantiomer was over 97.5% as determined by HPLC. Moreover, the recovery for (R,S)-ibuprofen from high-speed counter-current chromatography fractions was achieved in the range of 82–89%. |
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ISSN: | 0957-4166 1362-511X |
DOI: | 10.1016/j.tetasy.2016.03.001 |