An animal model for intractable chronic lymphocytic leukemia

Lymphomas developed in mice treated with X-irradiation. The radiosensitivity of cells of the lymphomas had a bimodal frequency distribution. The cells of 11 lymphomas had approximately the same radiosensitivity as normal murine lymphocytes; 6 lymphomas were highly radioresistant. Radioresistant and...

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Bibliographic Details
Published inMedical hypotheses Vol. 33; no. 3; pp. 175 - 176
Main Author Schrek, R.
Format Journal Article
LanguageEnglish
Published United States Elsevier Ltd 01.11.1990
Subjects
Animals
Disease Models, Animal
gamma-Linolenic Acid
Humans
Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy
Leukemia, Lymphocytic, Chronic, B-Cell - etiology
Leukemia, Lymphocytic, Chronic, B-Cell - radiotherapy
Linolenic Acids - therapeutic use
Lymphoma - drug therapy
Lymphoma - etiology
Lymphoma - radiotherapy
Mice
Radiation Tolerance
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Summary:Lymphomas developed in mice treated with X-irradiation. The radiosensitivity of cells of the lymphomas had a bimodal frequency distribution. The cells of 11 lymphomas had approximately the same radiosensitivity as normal murine lymphocytes; 6 lymphomas were highly radioresistant. Radioresistant and radiosensitive lymphomas were analogous to intractable chronic lymphocytic leukemia (CLL) and to responsive CLL in humans. The radioresistant lymphomas can be used to study the effect of therapeutic agents on the animal model for intractable CLL both in vitro and in vivo.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0306-9877
1532-2777
DOI:10.1016/0306-9877(90)90171-A