Intracerebral xenotransplantation: recent findings and perspectives for local immunosuppression

• Published in: Current opinion in organ transplantation Vol. 16; no. 2; p. 190
• Main Authors: Lévêque, Xavier, Cozzi, Emanuele, Naveilhan, Philippe, Neveu, Isabelle
• Format: Journal Article
• Language: English
• Published: United States 01.04.2011
• Subjects: Animals; Brain - immunology; Brain - surgery; Cell Survival; Graft Survival; Humans; Immunosuppressive Agents - therapeutic use; Nerve Regeneration; Neurons - immunology; Neurons - transplantation; Stem Cell Transplantation; Transplantation Tolerance; Transplantation, Heterologous; Treatment Outcome
• ISSN: 1531-7013
• DOI: 10.1097/MOT.0b013e32834494b5

Cell therapy is a promising strategy for tissue repair in the central nervous system. In this perspective, several cell types are being considered, including allogenic neuroblasts, embryonic stem cells and induced pluripotent stem cells. The use of allogenic neuroblasts as cell source is limited by logistics and ethical problems whereas transplantation of the last two cell types is hampered by their propensity to generate tumour. In this context, transplantation of xenogeneic neural cells appears as an attractive approach for effective neuronal replacement in case of neurodegenerative disorders. With the emergence of embryonic and induced pluripotent stem cells as potential cell source in regenerative medicine, little attention has been paid to the possibility of transplanting xenogenic neural cells in the central nervous system. However, recent progress to circumvent the host immune response in the brain has raised encouraging perspectives for intracerebral xenotransplantation as restorative strategy. To date, most of the immunosuppressive strategies designed for long-term survival of intracerebral neural transplants were based on systemic immunosuppression that has detrimental side-effects. The immunological status of the brain and the presence of the blood-brain barrier raise the possibility of local immunosuppression. This article provides an overview of the strategies recently developed to protect intracerebral neural transplants with special focus on local immunosuppression.