Acid activated montmorillonite K-10 mediated intramolecular acylation: Simple and convenient synthesis of 4-chromanones

[Display omitted] 3-Aryloxyproionic acids undergo intramolecular cyclization in the presence of AA.Mont.K-10 in toluene under reflux for 30–45 min in good to excellent yields. Phenyl ring bearing various substituents at the ortho, meta, para positions undergo this cyclization reaction. This method i...

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Published inTetrahedron letters Vol. 82; pp. 153372 - 153377
Main Authors Begum, Ayisha F., Balasubramanian, Kalpattu K., Shanmugasundaram, Bhagavathy
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 12.10.2021
Elsevier
Subjects
Aryloxypropionic acid
Chemistry
Chemistry, Organic
Clay catalyst
Friedal-Crafts acylation
Intramolecular cyclisation
Montmorillonite K-10
Physical Sciences
Science & Technology
Montmorillonite K-10
Aryloxypropionic acid
Friedal-Crafts acylation
Intramolecular cyclisation
Clay catalyst
FRIEDEL-CRAFTS ACYLATION
CHROMONE
EFFICIENT SYNTHESIS
CATALYZED ACYLATION
ALCOHOLS
THIOLS
PHENOLS
AMINES
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Summary:[Display omitted] 3-Aryloxyproionic acids undergo intramolecular cyclization in the presence of AA.Mont.K-10 in toluene under reflux for 30–45 min in good to excellent yields. Phenyl ring bearing various substituents at the ortho, meta, para positions undergo this cyclization reaction. This method involves simple work up and amenable for large scale preparations. The heterogeneous acid treated catalyst can be regenerated and used for up to three cycles with minimum loss of activity.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2021.153372