Evidence for the contribution by the cerebral cortex to 5-hydroxyindoleacetic acid found in the cerebrospinal fluid of cats

Perfusion of artificial CSF from a lateral ventricle to the cerebral cortical subarachnoid space in anaesthetized cats was used to study the contribution of the cerebral cortex to the concentration of 5-hydroxyindoleacetic acid (5-HIAA) in CSF. The technique did not cause rupture of the meninges. Th...

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Bibliographic Details
Published inBrain research Vol. 209; no. 1; p. 235
Main Authors Min-Chu, L, Mackenna, B R, Watt, J A
Format Journal Article
LanguageEnglish
Published Netherlands 23.03.1981
Subjects
Animals
Cats
Cerebral Cortex - physiology
Choroid Plexus - physiology
Hydroxyindoleacetic Acid - cerebrospinal fluid
Subarachnoid Space - physiology
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Summary:Perfusion of artificial CSF from a lateral ventricle to the cerebral cortical subarachnoid space in anaesthetized cats was used to study the contribution of the cerebral cortex to the concentration of 5-hydroxyindoleacetic acid (5-HIAA) in CSF. The technique did not cause rupture of the meninges. The use of [14C]5-HIAA and of probenecid suggested that there was a contribution and also a transport mechanism similar to that in the choroid plexus.
ISSN:0006-8993
DOI:10.1016/0006-8993(81)91187-2