Thrombotic Thrombocytopenic Purpura: What an Intensive Care Unit Doctor Needs to Know

Accurate and prompt diagnoses of thrombotic microangiopathy (TMA) in the emergency room (ER) and intensive care unit (ICU) setting can be challenging since its presentation involve multiple organ systems, and comorbid diseases can be deceptive for an accurate diagnosis.  Here, we present the case of...

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Published inCurēus (Palo Alto, CA) Vol. 12; no. 3; p. e7293
Main Authors Bethencourt-Mirabal, Arian, Rodriguez Cesar, Daylin, Ortet, Dalie, Hernandez, Felix, Ferrer, Gustavo
Format Journal Article
LanguageEnglish
Published United States Cureus Inc 16.03.2020
Cureus
Subjects
Acute coronary syndromes
Anemia
Blood clots
Blood platelets
Cardiology
Case reports
Critical care
Dehydrogenases
Enzymes
Hematology
Hospitals
Intensive care
Internal medicine
Ischemia
Laboratories
Mortality
Pain
Patients
Plasma
United States > US
acute coronary
peripheral blood
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Summary:Accurate and prompt diagnoses of thrombotic microangiopathy (TMA) in the emergency room (ER) and intensive care unit (ICU) setting can be challenging since its presentation involve multiple organ systems, and comorbid diseases can be deceptive for an accurate diagnosis.  Here, we present the case of a patient, who upon arrival to the ER, reported severe chest pain radiating to his left shoulder, diaphoresis, headache, and nausea. Several numbers of small petechiae on the bilateral lower extremities were also found during physical examination. Laboratory data demonstrated elevated troponin levels, platelet count of 34, and hemoglobin of  8.7 g/l. Establishing a differential diagnosis between a microvascular occlusive disorder and acute coronary syndrome was imperative to reduce further clinical complications and mortality. A peripheral smear, which is an essential test in approaching the diagnosis of thrombotic thrombocytopenic purpura (TTP), was done and it identified an increased number of schistocytes. The laboratory findings narrowed the diagnosis to an immunological process, where the dysfunctional platelets caused coronary thrombosis and further intermittent coronary ischemia. In this case report, we discuss the atypical presentation of TTP, its differential diagnosis, and management in order to develop an effective treatment in the ER and ICU settings and to reduce the mortality rate.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.7293