Significant Association of CCND1 Genotypes With Susceptibility to Childhood Acute Lymphoblastic Leukemia

• Published in: Anticancer research Vol. 41; no. 10; pp. 4801 - 4806
• Main Authors: HSU, PEI-CHEN, PEI, JEN-SHENG, CHEN, CHAO-CHUN, CHANG, WEN-SHIN, CHIN, YU-TING, HUANG, TAI-LIN, YANG, JAI-SING, WANG, YUN-CHI, CHEN, JAW-CHYUN, HSU, YUAN-NIAN, TSAI, CHIA-WEN, BAU, DA-TIAN
• Format: Journal Article
• Language: English
• Published: Athens International Institute of Anticancer Research 01.10.2021
• Subjects: Acute lymphoblastic leukemia; Age; Cancer; Cell cycle; Childhood; Children; Cyclin D1; Gender; Genetic diversity; Genotype & phenotype; Genotypes; Hypotheses; Investigations; Kinases; Leukemia; Lymphatic leukemia; Polymorphism; Risk reduction
• ISSN: 0250-7005; 1791-7530; 1791-7530
• DOI: 10.21873/anticanres.15295

Background/Aim: This study investigated whether genetic variations in cyclin D1 (CCND1) are associated with susceptibility to childhood acute lymphoblastic leukemia (ALL). Materials and Methods: A total of 266 childhood ALL cases and 266 healthy controls were genotyped for CCND1 rs9344 and rs678653. Results: There was a significant difference in the genotypic distribution of rs9344 between childhood ALL patients and healthy controls (p=0.0077). Compared to the AA genotype, AG and GG genotypes were associated with significantly decreased risks of childhood ALL with odds ratio (OR) of 0.65 [95% confidence interval (CI)=0.44-0.94, p=0.0234] and 0.45 (95%CI=0.26-0.78, p=0.0040), respectively. Supporting this, allelic frequency distributions between childhood ALL patients and controls was significantly different (OR=0.68, 95%CI=0.53-0.88, p=0.0025). There was no significant difference in the genotypic and allelic distributions of rs678653 between cases and controls. Conclusion: CCND1 rs9344, but not rs678653, may serve as a predictive marker of susceptibility for childhood ALL.