Three new diterpenoid alkaloids from Delphinium naviculare var. lasiocarpum W. T. Wang

[Display omitted] •Phytochemical study of endemic plant Delphinium naviculare var. lasiocarpum W. T. Wang in Xinjiang of China was performed.•Three new and five known diterpenoid alkaloids were isolated from D. naviculare var. lasiocarpum.•Their structures were established on the basis of spectrosco...

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Published inPhytochemistry letters Vol. 33; pp. 12 - 16
Main Authors Xue, Wen-Juan, Zhao, Bo, Zhao, Jiang-Yu, Sh. Sagdullaev, Sh, Akber Aisa, Haji
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.10.2019
Subjects
Cytotoxicity
Delphinium naviculare var. lasiocarpum
Diterpenoid alkaloids
Naviconine
Naviconitine
Naviculine
Delphinium naviculare var. lasiocarpum
Cytotoxicity
Naviconine
Diterpenoid alkaloids
Naviculine
Naviconitine
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Summary:[Display omitted] •Phytochemical study of endemic plant Delphinium naviculare var. lasiocarpum W. T. Wang in Xinjiang of China was performed.•Three new and five known diterpenoid alkaloids were isolated from D. naviculare var. lasiocarpum.•Their structures were established on the basis of spectroscopic analyses.•No cytotoxicity was observed against HT29, MDA-MB-231 and HeLa cancer cells of these diterpenoid alkaloids. Three new diterpenoid alkaloids, designated naviconine (1), naviculine (2) and naviconitine (3), together with five known diterpenoid alkaloids (4)–(8) were isolated from the whole plant of Delphinium naviculare var. lasiocarpum W. T. Wang. The structures of the new compounds were established on the basis of spectroscopic analyses including HR-ESI-MS, 1D and 2D NMR analyses. All of the compounds were evaluated in vitro for cytotoxicity against HT-29, MDA-MB-231 and HeLa cancer cell lines using the MTT method.
ISSN:1874-3900
1876-7486
DOI:10.1016/j.phytol.2019.06.009