Ultrasound-responsive smart composite biomaterials in tissue repair

• Published in: Nano today Vol. 49; p. 101804
• Main Authors: Han, Xiaoyu, Yi, Weiwei, Chen, Shuyu, Cai, Zhengwei, Zhu, Ying, Han, Wang, Guo, Xiya, Shen, Jieliang, Cui, Wenguo, Bai, Dingqun
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.04.2023
• Subjects: Remote control; Smart composite biomaterials; Tissue Repair; Trigger; Ultrasound; Tissue Repair; Trigger; Ultrasound; Smart composite biomaterials; Remote control
• ISSN: 1748-0132; 1878-044X
• DOI: 10.1016/j.nantod.2023.101804

Tissue repair is a cascade of sequential biological events initiated to repair damages inflicted by trauma, pathogenic bacteria, or other injury-causing factors, with the aim of restoring tissue integrity. Smart composite biomaterials are able to react to biological signals released after tissue damages and make adjustments that suit the dynamic and complex internal environment based on external information, thus maintaining the homeostasis of the internal environment in the human body. Ultrasound is considered as an excellent “remote control” and “trigger” for smart composite biomaterials due to its basic technical characteristic effects that primarily include cavitation, microstreaming, scattering, and acoustic radiation force. Here, we presented the first comprehensive and systematic review of the research progress of ultrasound-responsive smart composite biomaterials in tissue repair. In this review, firstly, we elaborated on the definition and mechanism of ultrasound, followed by a brief analysis of the principles of the response of biomaterials to ultrasound. Then, to systematically review the subject, we divide ultrasound-responsive smart composite biomaterials into following categories: anti-infective, skin repair, osteogenic, gene transfection, thrombolytic, neuromuscular, and imaging. Finally, there is a brief summary of ultrasound-responsive smart composite biomaterials, and an outlook based on characteristics of physiological repair of tissues in each system. [Display omitted] •The application cases of ultrasound-responsive biomaterials in tissue repair are discussed comprehensively and systematically.•The mechanism of generation and development of sound waves are discussed.•The mechanism of action of ultrasonic responsive biomaterials are discussed.•The strategies for improving the ultrasound-responsive biomaterials performance are illustrated.•The problems, opportunities, and challenges of ultrasound-responsive biomaterials in tissue repair are also discussed.