New lanostane-type triterpenoids, inonotsutriols D, and E, from Inonotus obliquus
New triterpenoids named inonotsutriols D ( 1) and E ( 2) were isolated from I. obliquus. Their structures were determined as lanost-8-ene-3β,22 R,24 R-triol ( 1) and lanost-8-ene-3β,22 R,24 S-triol ( 2). Compound 1 exhibited cytotoxic activity against four cancer cell lines (P388, L1210, HL-60, and...
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Published in | Phytochemistry letters Vol. 4; no. 3; pp. 328 - 332 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Elsevier Ltd
01.09.2011
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Subjects | |
Online Access | Get full text |
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Summary: | New triterpenoids named inonotsutriols D (
1) and E (
2) were isolated from
I. obliquus. Their structures were determined as lanost-8-ene-3β,22
R,24
R-triol (
1) and lanost-8-ene-3β,22
R,24
S-triol (
2). Compound
1 exhibited cytotoxic activity against four cancer cell lines (P388, L1210, HL-60, and KB).
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► New triterpenoids, inonotsutriols D (
1) and E (
2) were isolated from
I. obliquus. ► The structure of
1 was determined as lanost-8-ene-3β,22
R,24
R-triol. ► The structure of
2 was determined as lanost-8-ene-3β,22
R,24
S-triol. ► Cytotoxicities of compounds
1,
3–
8 were examined using P388, L1210, HL-60, and KB cell lines. ► Compound
1 exhibited cytotoxic activity against all four cancer cell lines.
Two new lanostane-type triterpenoids, inonotsutriols D (
1) and E (
2), were isolated from the sclerotia of
Inonotus obliquus (Pers.: Fr.) Pil. (Japanese name: kabanoanatake; Russian name: chaga). Their structures were determined to be lanost-8-ene-3β,22
R,24
R-triol (
1) and lanost-8-ene-3β,22
R,24
S-triol (
2) on the basis of spectral data, including 2D NMR analysis. In addition, major compounds, inotodiol (
3), trametenolic acid (
4), 3β-hydroxylanosta-8,24-dien-21-al (
5), 21-hydroxylanosterol (
6), inonotsuoxide A (
7) and inonotsuoxide B (
8) were identified, and all compounds, except
2, were evaluated for their cancer cell growth inhibitory activity against P388, HL-60, L1210 and KB cell lines. |
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ISSN: | 1874-3900 1876-7486 |
DOI: | 10.1016/j.phytol.2011.07.001 |