DKADE: a novel framework based on deep learning and knowledge graph for identifying adverse drug events and related medications

• Published in: Briefings in bioinformatics Vol. 24; no. 4
• Main Authors: Feng, Ze-Ying, Wu, Xue-Hong, Ma, Jun-Long, Li, Min, He, Ge-Fei, Cao, Dong-Sheng, Yang, Guo-Ping
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 20.07.2023; Oxford Publishing Limited (England)
• Subjects: Adaptability; Adverse events; Automation; Deep learning; Drugs; Knowledge representation; Natural language processing; Pharmacovigilance; Semantics; Side effects; deep learning; adverse drug events; knowledge graph; Chinese natural language processing
• ISSN: 1467-5463; 1477-4054
• DOI: 10.1093/bib/bbad228

Abstract Adverse drug events (ADEs) are common in clinical practice and can cause significant harm to patients and increase resource use. Natural language processing (NLP) has been applied to automate ADE detection, but NLP systems become less adaptable when drug entities are missing or multiple medications are specified in clinical narratives. Additionally, no Chinese-language NLP system has been developed for ADE detection due to the complexity of Chinese semantics, despite ˃10 million cases of drug-related adverse events occurring annually in China. To address these challenges, we propose DKADE, a deep learning and knowledge graph-based framework for identifying ADEs. DKADE infers missing drug entities and evaluates their correlations with ADEs by combining medication orders and existing drug knowledge. Moreover, DKADE can automatically screen for new adverse drug reactions. Experimental results show that DKADE achieves an overall F1-score value of 91.13%. Furthermore, the adaptability of DKADE is validated using real-world external clinical data. In summary, DKADE is a powerful tool for studying drug safety and automating adverse event monitoring.