Outcome of percutaneous coronary intervention versus coronary bypass grafting for patients with low left ventricular ejection fractions, unstable angina pectoris, and risk factors for adverse outcomes with bypass (the AWESOME Randomized Trial and Registry)

• Published in: The American journal of cardiology Vol. 94; no. 1; pp. 118 - 120
• Main Authors: Sedlis, Steven P, Ramanathan, Kodangudi B, Morrison, Douglass A, Sethi, Gulshan, Sacks, Jerome, Henderson, William
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.07.2004; Elsevier
• Subjects: Aged; Angina Pectoris - mortality; Angina Pectoris - pathology; Angina Pectoris - therapy; Angioplasty, Balloon, Coronary; Biological and medical sciences; Cardiac Output, Low - mortality; Cardiac Output, Low - pathology; Cardiac Output, Low - therapy; Cardiology. Vascular system; Coronary Artery Bypass; Coronary heart disease; Female; Heart; Humans; Male; Medical sciences; Prospective Studies; Registries; Survival Analysis; Treatment Outcome; United States; United States; Human; Prognosis; Angioplasty; Coronary artery; Instrumentation therapy; Cardiovascular disease; Coronary heart disease; Phlebology; Left ventricle; Randomization; Aortocoronary; Bypass; Low; Surgery; Risk factor; Complication; Evolution; Graft; Ventricular ejection; Circulatory system; Cardiology; Variant angina; Comparative study; Ejection fraction
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/j.amjcard.2004.03.041

The recently concluded Angina With Extremely Serious Operative Mortality Evaluation (AWESOME) was a randomized clinical trial of percutaneous coronary intervention versus coronary bypass graft surgery among patients with medically refractory ischemia who were at high risk for coronary bypass graft surgery because of ≥1 risk factors that included severely reduced left ventricular (LV) function, defined as LV ejection fraction <35%. This study reports the outcome of patients with LV ejection fraction <35% in the randomized clinical trial and the physician-directed and patient choice registries of the AWESOME study.