A general and convenient synthesis of N-aryl piperazines

A general and convenient synthesis of N-aryl piperazines from bis(2-chloroethyl)amine hydrochloride and a broad range of anilines in diethylene glycol monomethyl ether is described. A general and convenient synthesis of N-aryl piperazines from bis(2-chloroethyl)amine hydrochloride and a broad range...

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Bibliographic Details
Published inTetrahedron letters Vol. 46; no. 46; pp. 7921 - 7922
Main Authors Liu, Kevin G., Robichaud, Albert J.
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 14.11.2005
Elsevier
Subjects
Chemistry
Chemistry, Organic
N-Aryl piperazines
Physical Sciences
Science & Technology
N-Aryl piperazines
ANTAGONISTS
N-aryl piperazines
AMINATION
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Summary:A general and convenient synthesis of N-aryl piperazines from bis(2-chloroethyl)amine hydrochloride and a broad range of anilines in diethylene glycol monomethyl ether is described. A general and convenient synthesis of N-aryl piperazines from bis(2-chloroethyl)amine hydrochloride and a broad range of anilines in diethylene glycol monomethyl ether is described.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2005.09.092