2-Aryl-3-phenylamino-4,5-dihydro-2h-benz[g]indazoles with analgesic activity

• Published in: Farmaco (Società chimica italiana : 1989) Vol. 58; no. 9; pp. 845 - 849
• Main Authors: Schenone, Silvia, Bruno, Olga, Ranise, Angelo, Brullo, Chiara, Bondavalli, Francesco, Filippelli, Walter, Mazzeo, Filomena, Capuano, Annalisa, Falcone, Giuseppe
• Format: Journal Article
• Language: English
• Published: Lausanne Elsevier SAS 01.09.2003; Elsevier Science
• Subjects: 2-Aryl-3-phenylamino-4,5-dihydro-2H-benz[g]indazoles; Analgesic activity; Analgesics; Analgesics - chemical synthesis; Analgesics - pharmacology; Anesthetics, Local - chemical synthesis; Anesthetics, Local - pharmacology; Aniline Compounds - chemical synthesis; Aniline Compounds - pharmacology; Animals; Anti-Arrhythmia Agents - chemical synthesis; Anti-Arrhythmia Agents - pharmacology; Biological and medical sciences; Crystallization; Drug Compounding; Female; Indazoles - chemical synthesis; Indazoles - pharmacology; Injections, Intraperitoneal; Male; Medical sciences; Mice; Neuropharmacology; Pain Measurement; Pharmacology. Drug treatments; Rats; Structure-Activity Relationship; Transition Temperature; Ventricular Fibrillation - drug therapy; 2-Aryl-3-phenylamino-4,5-dihydro-2H-benz[g]indazoles; Analgesic activity; Nitrogen heterocycle; Rodentia; Tricyclic compound; Vertebrata; Mammalia; Analgesic; Structure activity relation; Mouse; Animal; Aromatic compound; 2-Aryl-3-phenylamino-4.5-dihydro-2H-benz[g]indazoles; Fluorine Organic compounds; Chemical synthesis
• ISSN: 0014-827X; 1879-0569
• DOI: 10.1016/S0014-827X(03)00142-3

A series of 2-aryl-3-phenylamino-4,5-dihydro-2H-benz[g]indazoles was synthesized and tested for antiarrhythmic, local anaesthetic and analgesic activity. The title compounds showed a good antinociceptive activity.