New substituted 2-(pyrazol-1-yl)-dialkylacetanilides with potential local anesthetic and antiarrhythmic action. Part II

• Published in: Farmaco (Società chimica italiana : 1989) Vol. 58; no. 4; pp. 301 - 307
• Main Authors: Iovu, Mircea, Zalaru, Christina, Dumitrascu, Florea, Draghici, Constantin, Moraru, Mircea, Cristea, Elena
• Format: Journal Article
• Language: English
• Published: Lausanne Elsevier SAS 01.04.2003; Elsevier Science
• Subjects: Acetanilides - chemical synthesis; Acetanilides - pharmacology; Acetanilides - toxicity; Anesthetics, Local - chemical synthesis; Anesthetics, Local - pharmacology; Anesthetics, Local - toxicity; Anesthetics. Neuromuscular blocking agents; Animals; Anti-Arrhythmia Agents - chemical synthesis; Anti-Arrhythmia Agents - pharmacology; Anti-Arrhythmia Agents - toxicity; Antiarrhythmics; Antiarythmic agents; Biological and medical sciences; Cardiovascular system; Lethal Dose 50; Local anesthetics; Magnetic Resonance Spectroscopy; Medical sciences; Mice; Neuropharmacology; Pharmacology. Drug treatments; Pyrazoles - chemical synthesis; Pyrazoles - pharmacology; Pyrazoles - toxicity; Pyrazolyl-acetanilides; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Toxicity Tests, Acute; Pyrazolyl-acetanilides; Local anesthetics; Antiarrhythmics; Nitrogen heterocycle; Rodentia; Antiarrhythmic agent; Local anesthetic; Vertebrata; Mammalia; Structure activity relation; Mouse; Animal; Quinidine; Pyrazole derivatives; Carboxamide; Lidocaine; Chemical synthesis; Anilide
• ISSN: 0014-827X; 1879-0569
• DOI: 10.1016/S0014-827X(02)00014-9

Nine substituted 2-(pyrazol-1-yl)-dialkylacetanilides were synthesized by N-alkylation of pyrazole and its derivatives with several 2-iodoacetanilides. The new compounds exhibited local anesthetic and antiarrhythmic actions. They have been characterized by elemental chemical analysis, UV–Vis, IR, 1H NMR, 13C NMR, SM spectra and pharmacology research.