Synthesis of ferrocenyl monospirooxindolopyrrolidines—a facile [3+2]-cycloaddition of azomethine ylides

One-pot synthesis of novel ferrocenylmonospirooxindolopyrrolidines has been accomplished in good yield via a facile [3+2]-cycloaddition reaction of several azomethine ylides, derived from isatin/5,7-dibromoisatin and sarcosine, with various ferrocene derivatives as the dipolarophile. The effect of s...

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Bibliographic Details
Published inTetrahedron letters Vol. 49; no. 29; pp. 4487 - 4490
Main Authors Suresh Babu, A.R., Raghunathan, R.
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 21.07.2008
Elsevier
Subjects
Azomethine ylide
Chemistry
Chemistry, Organic
Cycloaddition
Ferrocene
Oxindolopyrrolidines
Physical Sciences
Science & Technology
Spiroheterocycles
Cycloaddition
Oxindolopyrrolidines
Spiroheterocycles
Ferrocene
Azomethine ylide
IN-VITRO
cycloaddition
azomethine ylide
ONE-POT SYNTHESIS
MEDIATED 3+2 CYCLOADDITION
ANTIMALARIAL ACTIVITY
ferrocene
oxindolopyrrolidines
DERIVATIVES
spiroheterocycles
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Summary:One-pot synthesis of novel ferrocenylmonospirooxindolopyrrolidines has been accomplished in good yield via a facile [3+2]-cycloaddition reaction of several azomethine ylides, derived from isatin/5,7-dibromoisatin and sarcosine, with various ferrocene derivatives as the dipolarophile. The effect of solvent on the [3+2]-dipolar cycloaddition reaction is also studied.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2008.05.064