Meta-analysis shows strong positive association of the TNF-α gene with tumor stage in bladder cancer

• Published in: Urologia internationalis Vol. 89; no. 3; p. 337
• Main Authors: Yang, Zengyue, Lv, Yajie, Lv, Yali, Wang, Yong
• Format: Journal Article
• Language: English
• Published: Switzerland 01.01.2012
• Subjects: Case-Control Studies; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Neoplasm Invasiveness; Neoplasm Staging; Odds Ratio; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Risk; Tumor Necrosis Factor-alpha - genetics; Tumor Necrosis Factor-alpha - metabolism; Urinary Bladder Neoplasms - diagnosis; Urinary Bladder Neoplasms - metabolism
• ISSN: 1423-0399
• DOI: 10.1159/000341701

There is no consensus on the association between the tumor necrosis factor-α (TNF-α) gene promoter -308 A/G single nucleotide polymorphisms and bladder cancer risk. To obtain a more precise estimation of this correlation, we conducted a meta-analysis. The PubMed, MEDLINE, Cochrane Library and China National Knowledge Infrastructure (CNKI) databases were searched for relevant published studies. Seven case-control studies with a total of 1,311 cases and 1,436 controls were identified and analyzed. A notable correlation was observed between the TNF-α genotype and bladder cancer grade (AA+GA vs. GG; odds ratio 1.96, 95% confidence interval 1.37-2.80, p = 0.0002). In summary, this meta-analysis demonstrates that the TNF-α -308 AA+GA genotype may be a marker to the tumor-invasive stage of bladder cancer.