Dynamic control of function by light-driven molecular motors

• Published in: Nature reviews. Chemistry Vol. 1; no. 12
• Main Authors: van Leeuwen, Thomas, Lubbe, Anouk S., Štacko, Peter, Wezenberg, Sander J., Feringa, Ben L.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 29.11.2017; Nature Publishing Group
• Subjects: 639/638/403; 639/638/541; Analytical Chemistry; Biochemistry; Biological activity; Biological properties; Catalysis; Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Chirality; Coupling (molecular); Dynamic control; Inorganic Chemistry; Mechanical properties; Molecular machines; Molecular motors; Organic Chemistry; perspective; Physical Chemistry; Switches; Switching
• ISSN: 2397-3358; 2397-3358
• DOI: 10.1038/s41570-017-0096

The field of dynamic functional molecular systems has progressed enormously over the past few decades. By coupling the mechanical properties of molecular switches and motors to chemical and biological processes, exceptional control of function has been attained. Overcrowded alkene-based light-driven molecular motors are very attractive in this respect owing to their unique multistate photochemically and thermally induced switching processes and their helical chirality inversion in each switching step. However, extending our control over properties from the molecular scale to larger length scales is still a fundamental challenge. In this Perspective, we discuss recent developments that address this challenge, ranging from the application of these motors in catalysis and synthetic materials to the control of biological properties. We may now be positioned at the dawn of a new era in which artificial molecular motors are able to perform programmed tasks and dynamic functions akin to the biological machines that are found in daily life. Light-driven artificial molecular switches and motors afford dynamic control of various molecular systems, ranging from catalytic to biological. This Perspective provides insight into the challenges that must be addressed to transition the field from the proof-of-concept stage to realization of its myriad applications.