Independent regulation of serologically distinct idiotypes in F1 hybrid mice

We have investigated the regulation of expression of two distinct intrastrain cross-reactive idiotypes, CRIA and CRIC , characteristic of anti-p-azophenylarsonate (anti-Ar) antibodies of the A/J and BALB/c strains, respectively, in (BALB/c X A/J)F1 ( CAF1 ) mice. Such hybrid mice were found to synth...

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Bibliographic Details
Published inImmunogenetics (New York) Vol. 19; no. 5; p. 369
Main Authors Kresina, T F, Nelles, M J, Nisonoff, A, Brown, A R
Format Journal Article
LanguageEnglish
Published United States 01.01.1984
Subjects
Animals
Antibodies, Monoclonal
Antigen-Antibody Complex
Crosses, Genetic
Immunoglobulin Idiotypes - genetics
Mice
Mice, Inbred A
Mice, Inbred BALB C
Mice, Inbred Strains
Species Specificity
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Summary:We have investigated the regulation of expression of two distinct intrastrain cross-reactive idiotypes, CRIA and CRIC , characteristic of anti-p-azophenylarsonate (anti-Ar) antibodies of the A/J and BALB/c strains, respectively, in (BALB/c X A/J)F1 ( CAF1 ) mice. Such hybrid mice were found to synthesize antibodies with each idiotype when immunized against the Ar hapten group, although the expression of each was significantly reduced as compared with the parental strain. CAF1 mice were pretreated with idiotypic-specific antibody reagents and subsequently hyperimmunized against the Ar hapten. Analysis of the idiotypes present in immune sera showed that suppression of either CRI did not concomitantly suppress the expression of the other. Alteration of the expression of one idiotype was not, however, without influence on the other; the expression of CRIC was markedly enhanced in mice suppressed for CRIA.
ISSN:0093-7711
DOI:10.1007/BF00364641