Synthesis of coumarins derivatives via decarboxylative cross-coupling of coumarin-3-carboxylic acid with benzylic C(sp3)-H bond

[Display omitted] •C(sp3)-H bond activation.•Decarboxylative cross-coupling.•Coumarins Derivatives synthesis. The reaction of coumarin-3-carboxylic acid with benzylic C(sp3)-H bond was established in this paper. A series of 3-benzylcoumarin derivatives were efficiently isolated in moderated to high...

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Bibliographic Details
Published inTetrahedron letters Vol. 59; no. 46; pp. 4073 - 4075
Main Authors Hao, Shuang-hong, Li, Li-Xia, Dong, Dao-Qing, Wang, Zu-Li, Yu, Xian-Yong
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 14.11.2018
Elsevier
Subjects
C(sp3)-H bond
Chemistry
Chemistry, Organic
Coumarin
Coumarin-3-carboxylic acid
Cross-coupling
Decarboxylative
Physical Sciences
Science & Technology
C(sp3)-H bond
Cross-coupling
Coumarin-3-carboxylic acid
Coumarin
Decarboxylative
ALKYNOATES
SULFONYLATION
RADICAL CYCLIZATION
CONSTRUCTION
ARYLATION
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Summary:[Display omitted] •C(sp3)-H bond activation.•Decarboxylative cross-coupling.•Coumarins Derivatives synthesis. The reaction of coumarin-3-carboxylic acid with benzylic C(sp3)-H bond was established in this paper. A series of 3-benzylcoumarin derivatives were efficiently isolated in moderated to high yield using Cu(OAc)2 as catalyst and TBPB as oxidant.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2018.10.001