Carcinoembryonic Antigen, Carbohydrate Antigen 19-9, Cancer Antigen 125, Prostate-Specific Antigen and Other Cancer Markers: A Primer on Commonly Used Cancer Markers

Cancer markers are molecules produced by cancer cells which may serve to identify the presence of cancer. Cancer markers can be differentiated as serum-based, radiology-based and tissue-based, and are one of the most important tools in diagnosing, staging and monitoring of treatment of many cancers....

Full description

Saved in:
Bibliographic Details
Published inWorld journal of oncology Vol. 14; no. 1; pp. 4 - 14
Main Authors Desai, Shreya, Guddati, Achuta K
Format Journal Article
LanguageEnglish
Published Canada Elmer Press 01.02.2023
Subjects
Review
Prognostic markers
Tumor markers
AFP
Cancer screening
CA 19-9
LDH
CA 27-29
5-HIAA
Calcitonin
CA-125
B-hCG
Serum markers
CEA
PSA
Online AccessGet full text

Cover

More Information
Summary:Cancer markers are molecules produced by cancer cells which may serve to identify the presence of cancer. Cancer markers can be differentiated as serum-based, radiology-based and tissue-based, and are one of the most important tools in diagnosing, staging and monitoring of treatment of many cancers. The most used cancer markers are serum cancer markers due to its relative ease and lower cost of testing. However, serum cancer markers have poor mass screening utilization due to poor positive predictive value. Several markers such as prostate-specific antigen (PSA), beta-human chorionic gonadotropin (B-hCG), alpha-fetoprotein (AFP), and lactate dehydrogenase (LDH) are used to aid in diagnosis of cancer in cases of high suspicion. Serum markers such as carcinoembryonic antigen (CEA), AFP, carbohydrate antigen 19-9 (CA 19-9), and 5-hydroxyindoleacetic acid (5-HIAA) play a significant role in assessing disease prognosis as well as response to treatment. This work reviews the role of some of the biomarkers in the diagnosis and treatment of cancer.
ISSN:1920-4531
1920-454X
DOI:10.14740/wjon1425