Role of MicroRNA in linking diabetic retinal neurodegeneration and vascular degeneration

Diabetic retinopathy is the major cause of blindness in diabetic patients, with limited treatment options that do not always restore optimal vision. Retinal nerve degeneration and vascular degeneration are two primary pathological processes of diabetic retinopathy. The retinal nervous system and vas...

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Published inFrontiers in endocrinology (Lausanne) Vol. 15; p. 1412138
Main Authors Zhao, Haiyan, Cai, Yichen, Pan, Junhua, Chen, Qiu
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 04.07.2024
Subjects
Animals
Apoptosis
diabetes
diabetic retinal degeneration
diabetic retinal neurodegeneration
Diabetic Retinopathy - genetics
Diabetic Retinopathy - metabolism
Diabetic Retinopathy - pathology
Endocrinology
Humans
linkage role
microRNA
MicroRNAs - genetics
Oxidative Stress
Retina - metabolism
Retina - pathology
Retinal Degeneration - genetics
Retinal Degeneration - pathology
Retinal Vessels - pathology
vascular degeneration
diabetic retinal neurodegeneration
microRNA
linkage role
vascular degeneration
diabetes
diabetic retinal degeneration
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Summary:Diabetic retinopathy is the major cause of blindness in diabetic patients, with limited treatment options that do not always restore optimal vision. Retinal nerve degeneration and vascular degeneration are two primary pathological processes of diabetic retinopathy. The retinal nervous system and vascular cells have a close coupling relationship. The connection between neurodegeneration and vascular degeneration is not yet fully understood. Recent studies have found that microRNA plays a role in regulating diabetic retinal neurovascular degeneration and can help delay the progression of the disease. This article will review how microRNA acts as a bridge connecting diabetic retinal neurodegeneration and vascular degeneration, focusing on the mechanisms of apoptosis, oxidative stress, inflammation, and endothelial factors. The aim is to identify valuable targets for new research and clinical treatment of diabetic retinopathy.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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Reviewed by: Donato Santovito, Ludwig Maximilian University of Munich, Germany
Israr Ahmad, University of Alabama at Birmingham, United States
Edited by: Imtaiyaz Hassan, Jamia Millia Islamia, India
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2024.1412138