The metabolic action of gestagens on the cerebral cortex of the guinea pig

The injection of chlormadinone acetate (CA) or norgestrel (N) potentiated the effects of estradiol (E 2) on RNA synthesis in the guinea pig cerebral cortex, but not in the uterus. Only CA inhibited the stimulation of protein synthesis by E 2 in the cerebral cortex. In contrast, the E 2-induced incre...

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Bibliographic Details
Published inContraception (Stoneham) Vol. 12; no. 2; pp. 221 - 228
Main Authors Pedroza, Escipión, Rosner, Jorge M.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.08.1975
Subjects
Animals
Cerebral Cortex - drug effects
Cerebral Cortex - metabolism
Chlormadinone Acetate - pharmacology
Cytidine - metabolism
Drug Synergism
Estradiol - pharmacology
Female
Guinea Pigs
Leucine - metabolism
Norgestrel - pharmacology
RNA - biosynthesis
Tritium
Uterus - metabolism
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Summary:The injection of chlormadinone acetate (CA) or norgestrel (N) potentiated the effects of estradiol (E 2) on RNA synthesis in the guinea pig cerebral cortex, but not in the uterus. Only CA inhibited the stimulation of protein synthesis by E 2 in the cerebral cortex. In contrast, the E 2-induced increment of protein synthesis in the uterus was not affected by the administration of either gestagen. When injected alone neither gestagen showed any metabolic action on the brain, indicating that their effects on RNA and protein synthesis in the cerebral cortex requires the presence of E 2.
ISSN:0010-7824
1879-0518
DOI:10.1016/S0010-7824(75)80025-4