Synthesis of a tripeptide biomarker of exposure to sulfur mustard for support of OPCW biomedical proficiency tests

[Display omitted] S-[2-(2-Hydroxyethylthio)ethyl]-Cys-Pro-Phe (HETE–CPP) was synthesized in seven steps as a reference compound for the development of a procedure for its quantification in blood plasma in the OPCW biomedical proficiency tests.

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Bibliographic Details
Published inMendeleev communications Vol. 31; no. 6; pp. 867 - 868
Main Authors Abzianidze, Victoria V., Chelusnova, Yulia V., Karakashev, Georgy V., Kochura, Dmitrii M., Leninskii, Michael A., Yu. Gorbunov, Alexander, Shachneva, Mariya D., Krivorotov, Denis V., Ukolov, Anton I.
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.11.2021
Subjects
collision-induced dissociation
OPCW
peptide synthesis
positive control
qualitative and quantitative analysis
sulfides
sulfur mustard
tripeptides
OPCW
positive control
collision-induced dissociation
sulfur mustard
peptide synthesis
qualitative and quantitative analysis
sulfides
tripeptides
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Summary:[Display omitted] S-[2-(2-Hydroxyethylthio)ethyl]-Cys-Pro-Phe (HETE–CPP) was synthesized in seven steps as a reference compound for the development of a procedure for its quantification in blood plasma in the OPCW biomedical proficiency tests.
ISSN:0959-9436
DOI:10.1016/j.mencom.2021.11.033