A versatile protocol for the preparation of substituted 1- and 2-naphthyl piperazines from aminonaphthols

Aminonaphthols are easily transformed into a variety of 1- and 2-naphthyl piperazines using a sequence of diazotization reaction, iodide substitution and Pd(0) catalyzed coupling reaction. Aminonaphthols are easily transformed into a variety of 1- and 2-naphthyl piperazines using a sequence of diazo...

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Bibliographic Details
Published inTetrahedron letters Vol. 46; no. 45; pp. 7769 - 7771
Main Authors Bueno, Ana B., Flynn, Claire J., Gilmore, Jeremy, Marcos, Alicia, Montero, Carlos, Porter, Warren, Williams, Andrew C.
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 07.11.2005
Elsevier
Subjects
Chemistry
Chemistry, Organic
Diazotization
Palladium coupling
Physical Sciences
Science & Technology
Diazotization
AGENTS
diazotization
palladium coupling
DERIVATIVES
ARYL CHLORIDES
PALLADIUM-CATALYZED AMINATION
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Summary:Aminonaphthols are easily transformed into a variety of 1- and 2-naphthyl piperazines using a sequence of diazotization reaction, iodide substitution and Pd(0) catalyzed coupling reaction. Aminonaphthols are easily transformed into a variety of 1- and 2-naphthyl piperazines using a sequence of diazotization, iodide substitution and Pd(0) catalyzed coupling reactions.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2005.09.052