Platinum(II) complexes of imidazophenanthroline-based polypyridine ligands as potential anticancer agents: Syntheses, characterization, and in vitro cytotoxicity studies

• Published in: Inorganic chemistry communications Vol. 78; pp. 17 - 20
• Main Authors: Alexander, Carlson, Nithyakumar, A., Arockia Samy, N.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.04.2017
• ISSN: 1387-7003; 1879-0259
• DOI: 10.1016/j.inoche.2017.02.002

The synthesis of Pt(II) complexes of anthracene- and pyrene-conjugated imidazophenanthroline ligands and their in vitro cytotoxicity studies are reported. The cell viability and cytotoxicity studies of [Pt(AIP)(phen)](PF6)2 (1) and [Pt(PIP)(bpy)](PF6)2 (2) demonstrate inhibition of HeLa cell proliferation and apoptotic cell death. The molecular docking study reveals their intercalation into the major and minor grooves of the DNA. Platinum(II) complexes of anthracene- and pyrene-conjugated imidazophenanthroline ligands and their cytotoxicity against HeLa cell lines are reported. Inhibition of cell proliferation and apoptotic cell death lend support to their anticancer activity. The energy-optimized structures of the complexes and their intercalation into the DNA from molecular docking study are also reported. [Display omitted] •Pt(II) complexes of imidazophenanthroline based ligands and their cytotoxicity against HeLa cell lines are reported.•Inhibition of cell proliferation and apoptotic cell death lend support to their anticancer activity.•The energy-optimized structures of the complexes and their intercalation into DNA from docking study are reported.