Dendritic and lipid-based carriers for gene/siRNA delivery (a review)

• Published in: Current opinion in solid state & materials science Vol. 16; no. 6; pp. 310 - 322
• Main Authors: Sheikhi Mehrabadi, Fatemeh, Fischer, Wiebke, Haag, Rainer
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.12.2012
• Subjects: Dendritic carrier; Lipid based carrier; Lipoplex; Polyplex; siRNA delivery; siRNA delivery; Lipid based carrier; Polyplex; Dendritic carrier; Lipoplex
• ISSN: 1359-0286
• DOI: 10.1016/j.cossms.2013.01.003

[Display omitted] ► Recent advances in the field of siRNA in vitro and in vivo delivery. ► Overview on development of dendritic carriers for siRNA delivery. ► Recent developments of lipid-based carriers for siRNA delivery. RNA-based therapeutics has emerged as a novel and powerful approach for targeting a broad range of human diseases. Currently, a number of RNA-based drugs are under clinical investigation. The development of such drugs, however, has been slow and encountered multiple challenges. The clinical progress of such therapeutics strongly depends on whether a delivery vehicle efficiently and safely directs the drug into the target cells. Among the variety of non-viral vectors, dendritic carriers are particularly attractive due to their unique molecular architectures, globular shape, and multivalent groups on their surface. Lipid-based vectors were among the earliest strategies used for gene transfection and they are the most studied carriers for siRNA delivery. However, so far only a few of such systems have been studied in vivo. This review focuses on the most widely studied dendritic as well as lipid-based carriers for gene/siRNA delivery.