Memory, Sleep, and Tau Function

 Memory consolidation related to the hippocampal-cortex connection takes place during sleep. This connection may involve at least two steps- one in the NREM phase of sleep (transmission) and the other in the REM phase (consolidation). In this brief report, we comment on the role of tau protein in th...

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Bibliographic Details
Published inJournal of Alzheimer's disease Vol. 94; no. 2; p. 491
Main Authors Avila, Jesús, Perry, George
Format Journal Article
LanguageEnglish
Published Netherlands 01.01.2023
Subjects
sleep
tau
delta waves
memory
Alzheimer’s disease
NREM phase
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Summary: Memory consolidation related to the hippocampal-cortex connection takes place during sleep. This connection may involve at least two steps- one in the NREM phase of sleep (transmission) and the other in the REM phase (consolidation). In this brief report, we comment on the role of tau protein in these two phases of sleep. The absence of tau decreases δ waves in NREM, whereas the overexpression of modified (phosphorylated and/or mutated) tau alters θ waves in REM.
ISSN:1875-8908
DOI:10.3233/JAD-230230