Neuroinflammation and the blood–brain interface: New findings in brain pathology

Two fundamental concepts have impeded the development of research in brain, behavior and immunity during the past century. They have been presented in neuroscience textbooks since the beginning of the 20th century. Recent discoveries require that both views are in serious need of being updated in th...

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Bibliographic Details
Published inClinical & experimental neuroimmunology Vol. 11; no. 1; pp. 16 - 20
Main Authors Kelley, Keith W., Shimada, Atsuyoshi
Format Journal Article
LanguageEnglish
Published Ube Wiley Subscription Services, Inc 01.02.2020
Subjects
Blood-brain barrier
blood–brain interface
brain endothelia
Central nervous system
choroid plexus
Immune privilege
Inflammation
Lymphatic drainage
meningeal lymphatics
Nervous system
pericytes
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Summary:Two fundamental concepts have impeded the development of research in brain, behavior and immunity during the past century. They have been presented in neuroscience textbooks since the beginning of the 20th century. Recent discoveries require that both views are in serious need of being updated in the scientific literature and medical textbooks. These two age‐old concepts are lack of lymphatic drainage in the brain and immune privilege of the central nervous system associated with impermeability of the blood–brain barrier. Cellular and tissue components comprise the brain–immune interface in both normal physiology and neuroinflammation. Recent discoveries in meningeal lymphatics, blood–brain transport, brain myeloid cells and pericytes, and movement of cells from blood through the choroid plexus into the brain parenchyma are highlighted.
ISSN:1759-1961
1759-1961
DOI:10.1111/cen3.12558