Preparation of pesticide microspheres based on polylactic acid: optimized by response surface methodology

Polylactic acid, as a kind of environment-friendly material, has excellent biodegradability, biocompatibility and plasticity. In recent years, it has been widely used in medicine, packaging and other fields, but rarely in agriculture. In this study, the process of buprofezin - polylactic acid micros...

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Bibliographic Details
Published inIOP conference series. Materials Science and Engineering Vol. 711; no. 1; pp. 12026 - 12032
Main Authors Li, Yan, Dai, Jiakun, Cao, Duo, Ma, Yu, Zhen, Lisha, Chang, Fan
Format Journal Article
LanguageEnglish
Published Bristol IOP Publishing 01.01.2020
Subjects
Biocompatibility
Biodegradability
Encapsulation
Microspheres
Particle size
Particle size distribution
Pesticides
Polylactic acid
Response surface methodology
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Summary:Polylactic acid, as a kind of environment-friendly material, has excellent biodegradability, biocompatibility and plasticity. In recent years, it has been widely used in medicine, packaging and other fields, but rarely in agriculture. In this study, the process of buprofezin - polylactic acid microsphere was optimized by response surface method. Changing parameters, especially the concentration of PLA and the PLA/drug ratio, can increase the encapsulation efficiency of buprofezin - PLA microspheres. Ultimately, the highest encapsulation efficiency reached to 96.47%. The result of FESEM and laser particle size distribution analyzer showed that the microspheres have smooth surface and good dispersion, with particle size of 34.2 μm.
ISSN:1757-8981
1757-899X
DOI:10.1088/1757-899X/711/1/012026