Strategies Towards the Synthesis of N2-Substituted 1,2,3-Triazoles

• Published in: Anais da Academia Brasileira de Ciências Vol. 91; no. suppl 1; p. e20180751
• Main Authors: SOUZA, RODRIGO OCTÁVIO M.A. DE, MIRANDA, LEANDRO S. DE MARIZ E
• Format: Journal Article
• Language: English
• Published: Brazil Academia Brasileira de Ciências 14.02.2019
• Subjects: 1,2,3-Triazoles; arylation; Catalysis; Cycloaddition Reaction; Heterocycles; Molecular Structure; MULTIDISCIPLINARY SCIENCES; Regiosselectivity; Triazoles - chemical synthesis; Triazoles - chemistry; 1,2,3-Triazoles; Heterocycles; Regiosselectivity; arylation

The chemistry of 1,2,3-triazoles gained much attention since the discovery of the copper catalyzed Alkyne-azide cycloaddition (CuAAC) reaction which delivers exclusively the 1,4-regioisomer in high yields. On the other hand there is still no universal methodology capable of delivering the N2 substit...