Strategies Towards the Synthesis of N2-Substituted 1,2,3-Triazoles

The chemistry of 1,2,3-triazoles gained much attention since the discovery of the copper catalyzed Alkyne-azide cycloaddition (CuAAC) reaction which delivers exclusively the 1,4-regioisomer in high yields. On the other hand there is still no universal methodology capable of delivering the N2 substit...

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Published inAnais da Academia Brasileira de Ciências Vol. 91; no. suppl 1; p. e20180751
Main Authors SOUZA, RODRIGO OCTÁVIO M.A. DE, MIRANDA, LEANDRO S. DE MARIZ E
Format Journal Article
LanguageEnglish
Published Brazil Academia Brasileira de Ciências 14.02.2019
Subjects
1,2,3-Triazoles
arylation
Catalysis
Cycloaddition Reaction
Heterocycles
Molecular Structure
MULTIDISCIPLINARY SCIENCES
Regiosselectivity
Triazoles - chemical synthesis
Triazoles - chemistry
1,2,3-Triazoles
Heterocycles
Regiosselectivity
arylation
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Summary:The chemistry of 1,2,3-triazoles gained much attention since the discovery of the copper catalyzed Alkyne-azide cycloaddition (CuAAC) reaction which delivers exclusively the 1,4-regioisomer in high yields. On the other hand there is still no universal methodology capable of delivering the N2 substituted regioisomer. The unique properties of these N2-substituted 1,2,3-triazoles have stimulated synthetic efforts on the developments of methodologies capable of delivering it in high yield and selectivity. These efforts are the subject of the presented review.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0001-3765
1678-2690
1678-2690
DOI:10.1590/0001-3765201820180751