Fat emulsion catabolism in vitro and in vivo--sex related differences

The removal rates of an intravenously administered 10% fat emulsion (Intralipid) from plasma in male and female conscious rats are described. The plasma concentration of fat emulsion particles at various time intervals following a bolus administration (0.2 g/kg) was measured by nephelometry. At the...

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Published inJPEN. Journal of parenteral and enteral nutrition Vol. 5; no. 3; p. 200
Main Authors Jesmok, G J, Woods, E F, Ditzler, W S, Walsh, G
Format Journal Article
LanguageEnglish
Published United States 01.05.1981
Subjects
Animals
Fat Emulsions, Intravenous - metabolism
Female
Kinetics
Lipids - blood
Lipoprotein Lipase - blood
Male
Parenteral Nutrition
Rats
Sex Factors
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Summary:The removal rates of an intravenously administered 10% fat emulsion (Intralipid) from plasma in male and female conscious rats are described. The plasma concentration of fat emulsion particles at various time intervals following a bolus administration (0.2 g/kg) was measured by nephelometry. At the dose employed, the removal of fat emulsion from the plasma followed first order kinetics, ie, a constant fraction was removed from the plasma per unit of time, K2 (%/min). Females exhibited a significantly greater fractional removal rate (K2) than comparably aged males (21.0 +/- 1.0 vs 15.0 +/- 1.4, p less than 0.05). Postheparin lipoprotein lipase, measured using fat emulsion as substrate, also was significantly greater in female rats compared with males. Our results demonstrate that, in rats, fat emulsion (Intralipid) is catabolized more rapidly in females than in males and a greater lipoprotein lipase activity in female rats may be the causative factor.
ISSN:0148-6071
DOI:10.1177/0148607181005003200