Influence of maternal high-fat diet on offspring's locomotor activity during anxiety-related behavioral tests: A systematic review

• Published in: Behavioural brain research Vol. 462; p. 114869
• Main Authors: Cavalcanti, Carolina Cadete Lucena, Manhães-de-Castro, Raul, Chaves, Wenicios Ferreira, Cadena-Burbano, Erika Vanesa, Antonio-Santos, José, da Silva Aragão, Raquel
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 28.03.2024
• Subjects: Locomotor activity; Maternal nutrition; Offspring behavior; MLR; EPM; HFD; Offspring behavior; Cnf; 5-HT; Locomotor activity; PPN; Maternal nutrition
• ISSN: 0166-4328; 1872-7549; 1872-7549
• DOI: 10.1016/j.bbr.2024.114869

The aim of this review was to summarize and discuss the impact of a maternal high-fat diet on the locomotor activity of offspring during anxiety-related behavioral tests. A search was performed in the LILACS, Web of Science, SCOPUS and PUMBED databases, using the following inclusion criteria: studies in which rodent dams were submitted to a high-fat diet during gestation and/or lactation and in which the locomotor activity parameters of offspring were evaluated during an anxiety-related test. Twenty-three articles met these criteria and were included. Most studies, 14 out of 23, found that a maternal high-fat diet did not alter offspring locomotor activity. Six articles found that a maternal high-fat diet increased the locomotor activity of offspring, while three found decreased locomotion. This effect may be associated with the initial response to the test and the fact that it was the first day of exposure to the apparatus. [Display omitted] ●In most of the studies, maternal HFD was found not to affect offspring’s locomotor activity.●Methodological differences in relation to maternal diet and age of the animals make comparisons between studies difficult.●The influence of various neurotransmitter systems on locomotion is discussed.