Senescent cells damage the body throughout life

Cells in a state of arrested growth, called senescence, have been characterized in skeletal muscle in mice. Senescent cells promote inflammation and block regeneration, and thus might induce harmful changes in aged muscle. Muscle injury induces cell senescence, which promotes inflammation.

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Bibliographic Details
Published inNature (London) Vol. 613; no. 7942; pp. 30 - 31
Main Author Glass, David J.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 05.01.2023
Nature Publishing Group
Subjects
631/136/7
631/532
631/532/489
Age
Aging
Animals
Cellular Senescence
Chromatin
Collagen
Gene expression
Genes
Genetic engineering
Geriatrics
Humanities and Social Sciences
Inflammation
Mitochondria
multidisciplinary
Muscle function
Muscles
Musculoskeletal system
News And Views
Older people
Organelles
Science
Senescence
Stem cells
Regeneration
Ageing
Stem cells
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Summary:Cells in a state of arrested growth, called senescence, have been characterized in skeletal muscle in mice. Senescent cells promote inflammation and block regeneration, and thus might induce harmful changes in aged muscle. Muscle injury induces cell senescence, which promotes inflammation.
Bibliography:SourceType-Other Sources-1
ObjectType-News-1
ObjectType-Commentary-2
content type line 66
ISSN:0028-0836
1476-4687
DOI:10.1038/d41586-022-04430-9