Metabolic control in diabetic patients. Effect of insulin-secretory reserve (measured by plasma C-peptide levels) and circulating insulin antibodies

• Published in: Diabetes (New York, N.Y.) Vol. 28; no. 8; pp. 749 - 753
• Main Authors: Gonen, B., Goldman, J., Baldwin, D., Goldberg, R. B., Ryan, W. G., Blix, P. M., Schanzlin, D., Fritz, K. J., Rubenstein, A. H.
• Format: Journal Article
• Language: English
• Published: American Diabetes Association 01.01.1979
• ISSN: 0012-1797; 1939-327X; 0012-1797
• DOI: 10.2337/diabetes.28.8.749

Metabolic control in diabetic patients. Effect of insulin-secretory reserve (measured by plasma C-peptide levels) and circulating insulin antibodies. B Gonen , J Goldman , D Baldwin , R B Goldberg , W G Ryan , P M Blix , D Schanzlin , K J Fritz and A H Rubenstein Abstract We measured circulating hemoglobin A1 (HbA1) and fasting plasma C-peptide concentrations in 100 diabetic patients. Pancreatic insulin reserve showed a negative correlation with HbA1 concentrations in nonobese, insulin-treated patients but not in obese patients, whether they were treated with insulin, oral agent, or diet alone. Patients with fasting C-peptide concentrations above 0.1 pmol/ml had significantly better metabolic control than did those with lower values. Anti-insulin antibodies were measured in 37 patients. There was no correlation between metabolic control and the affinity constants or binding capacities of these antibodies.