Getting to know ovarian cancer: Focusing on the effect of LncRNAs in this cancer and the effective signaling pathways

• Published in: Pathology, research and practice Vol. 254; p. 155084
• Main Authors: Alzahrani, Abdullah Ali, Almajidi, Yasir Qasim, Jasim, Saade Abdalkareem, Hjazi, Ahmed, Olegovich, Bokov Dmitry, Alkhafaji, Adnan Taan, Abdulridui, Hussam Abdali, Ahmed, Batool Ali, Alawadi, Ahmed, Alsalamy, Ali
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 01.02.2024
• Subjects: LncRNA- HOTAIR; LncRNAs; Ovarian cancers; Signaling pathways; FDA; LncRNA- HOTAIR; Signaling pathways; JAK/STAT3; NBAT-1; PI3K; TAMs; mTOR; Ovarian cancers; PSA; OSE; PCA3; IL-6R; RNAi; OS; EGF; VEGF; LncRNAs; ASOs; MAPK; EMT; IL-6; HGP; CDK4; HUVECs
• ISSN: 0344-0338; 1618-0631
• DOI: 10.1016/j.prp.2023.155084

This article undertakes a comprehensive investigation of ovarian cancer, examining the complex nature of this challenging disease. The main focus is on understanding the role of long non-coding RNAs (lncRNAs) in the context of ovarian cancer (OC), and their regulatory functions in disease progression. Through extensive research, the article identifies specific lncRNAs that play significant roles in the intricate molecular processes of OC. Furthermore, the study examines the signaling pathways involved in the development of OC, providing a detailed comprehension of the underlying molecular mechanisms. By connecting lncRNA dynamics with signaling pathways, this exploration not only advances our understanding of ovarian cancer but also reveals potential targets for therapeutic interventions. The findings open up opportunities for targeted treatments, highlighting the importance of personalized approaches in addressing this complex disease and driving progress in ovarian cancer research and treatment strategies.