Assessment of clinical-instrumental, morphological data and expression of coxsackie adenovirus receptor in patients with inflammatory cardiac pathology

• Published in: Kardiologiia Vol. 54; no. 5; p. 8
• Main Authors: Gupalo, E M, Mironova, N A, Rogova, M M, Chumachenko, P V, Tkachev, G A, Naumova, M A, Narusov, O Iu, Gerasimova, V V, Bakalov, S A, Samko, A M, Buriachkovskaia, L I, Tereshchenko, S N, Golitsyn, S P
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.01.2014
• Subjects: Adult; Arrhythmias, Cardiac - diagnosis; Arrhythmias, Cardiac - etiology; Arrhythmias, Cardiac - immunology; Arrhythmias, Cardiac - physiopathology; Biopsy; Brugada Syndrome; Bundle-Branch Block - immunology; Bundle-Branch Block - physiopathology; Cardiac Conduction System Disease; Coxsackie and Adenovirus Receptor-Like Membrane Protein - immunology; Female; Heart Conduction System - abnormalities; Heart Conduction System - immunology; Heart Conduction System - physiopathology; Heart Failure - diagnosis; Heart Failure - etiology; Heart Failure - physiopathology; Heart Function Tests - methods; Heart Ventricles - pathology; Heart Ventricles - physiopathology; Humans; Male; Middle Aged; Monitoring, Immunologic; Myocarditis - complications; Myocarditis - immunology; Myocarditis - pathology; Prognosis; Risk Assessment; Severity of Illness Index; Statistics as Topic
• ISSN: 0022-9040
• DOI: 10.18565/cardio.2014.5.8-15

In 22 patients with heart failure and/or ventricular arrhythmias presumably of inflammatory etiology the results of clinical and instrumental investigation were analyzed and compared to the endomyocardial biopsy data. In the subgroup of patients with left bundle branch block (LBBB) we revealed features indicative of lesser contribution of inflammatory destruction in pathogenesis of cardiomyopathy. The only virus, detected in biopsy samples, was parvovirus B19. Its persistence in myocardium was not related to activity of inflammation and severity of clinical course. Increased expression of Coxsackie adenovirus receptor (CAR) was found in 20 patients. It was not related to inflammatory cells infiltration and virus persistence in myocardium. Patients with most prominent CAR expression were characteried by right heart dilatation, more severe heart failure and absence of LBBB. Enhancement of CAR expression could reflect the attempt of organism to repair intercellular communications between cardiomyocites and to protect cells from the products of necrotic lysis during long standing inflammation.