Brain-derived neurotrophic factor in the nucleus tractus solitarii modulates glucose homeostasis after carotid chemoreceptor stimulation in rats

Neuronal systems, which regulate energy intake, energy expenditure and endogenous glucose production, sense and respond to input from hormonal related signals that convey information from body energy availability. Carotid chemoreceptors (CChr) function as sensors for circulating glucose levels and c...

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Bibliographic Details
Published inAdvances in experimental medicine and biology Vol. 758; p. 233
Main Authors Montero, Sergio, Cuéllar, Ricardo, Lemus, Mónica, Avalos, Reyes, Ramírez, Gladys, de Álvarez-Buylla, Elena Roces
Format Journal Article
LanguageEnglish
Published United States 01.01.2012
Subjects
Animals
Blood Glucose - analysis
Brain-Derived Neurotrophic Factor - physiology
Carotid Body - physiology
Homeostasis
Male
Rats
Rats, Wistar
Sodium Cyanide - pharmacology
Solitary Nucleus - physiology
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Summary:Neuronal systems, which regulate energy intake, energy expenditure and endogenous glucose production, sense and respond to input from hormonal related signals that convey information from body energy availability. Carotid chemoreceptors (CChr) function as sensors for circulating glucose levels and contribute to glycemic counterregulatory responses. Brain-derived neurotrophic factor (BDNF) that plays an important role in the endocrine system to regulate glucose metabolism could play a role in hyperglycemic glucose reflex with brain glucose retention (BGR) evoked by anoxic CChr stimulation. Infusing BDNF into the nucleus tractus solitarii (NTS) before CChr stimulation, showed that this neurotrophin increased arterial glucose and BGR. In contrast, BDNF receptor (TrkB) antagonist (K252a) infusions in NTS resulted in a decrease in both glucose variables.
ISSN:0065-2598
DOI:10.1007/978-94-007-4584-1_32